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. 2017 Feb 27;174(8):641–656. doi: 10.1111/bph.13727

Figure 3.

Figure 3

bpV(pis) increases p‐ERK1/2 independently of PTEN inhibition. (A) The p‐ERK1/2 is increased in SH‐SY5Y cells treated with bpV(pis) (20–200 nM); n = 7 independent cultures, *P < 0.05 versus Vehicle, one‐way ANOVA, followed by the Bonferroni post hoc test. (B) The effect of bpV(pis) (200 nM) on p‐ERK1/2 in SH‐SY5Y cells transfected with siRNApten; n = 6 independent cultures, *P < 0.05 versus NsiRNA + Vehicle; one‐way ANOVA, followed by the Bonferroni post hoc test. (C) p‐ERK1/2 is increased in U251 cells treated with bpV(pis) (20–200 nM); n = 6 independent cultures, *P < 0.05 versus Vehicle, one‐way ANOVA, followed by the Bonferroni post hoc test. (D) bpV(pis) does not activate ERK1/2 in vitro; n = 6 independent cultures.