Table 2. Recommendations for the Clinical Management of Hyperglycemic Events by Symptom Severity [31].

Grade	1	2	3	4
Glucose level, mg/dL	ULN-160	160–250	250–500	>500
Treatment	SMBG No treatment	SMBG Treat according to standard guidelines
Everolimus dose adjustment	None	None If intolerable, temporary interruption until recovery to grade 1 or less, then restart at same dose	Temporary interruption; restart at reduced dose	Discontinue

ULN, upper limit of normal; SMBG, self-monitoring of blood glucose.