Fig. 2. Activation of sterol regulatory element binding protein (SREBP). SREBPs are synthesized as inactive precursors that exist in the endoplasmic reticulum (ER) membrane. SREBP cleavage activating protein (SCAP) escorts SREBPs from the ER to the Golgi where two proteases release the NH2-teminal region of SREBPs. The NH2-teminal region of SREBPs moves to the nucleus and activates transcription of the target genes. INSIG, insulin induced gene; bHLH, basic helix-loop-helix.
