Fig. 3. Reduced adiponectin levels induce brain metabolism alterations and consequently Alzheimer's disease. (A) Healthy adipose cells release adiponectin actively. Adiponectin regulates glucose metabolism and oxidases fatty acids in the brain in normal conditions. (B) Hypertrophic adipose cells induced by obesity elicit a pro-inflammatory environment and reduce adiponectin production. Reduced adiponectin causes energy shortages in the brain due to reduced fatty acid oxidation and dysregulated glucose metabolism. This induces brain metabolism alterations and progressively leads to Alzheimer's disease. HIF 1α, hypoxia inducible factor 1α.
