Table 2.
Density of SYNSERT+ synaptic triads
| Brain region | Density of SYNSERT+ synaptic triads per 103 μm3 of SERT+ fiber | |||||
|---|---|---|---|---|---|---|
| Excitatory (mean ± SEM; % ± SEM) | Inhibitory (mean ± SEM; % ± SEM) | |||||
| Pre | Post | Equidistant | Pre | Post | Equidistant | |
| mPFC | 72 ± 10 | 55 ± 8 | 214 ± 25 | 17 ± 3 | 7 ± 1 | 20 ± 4 |
| 20 ± 1 | 15 ± 1 | 65 ± 1.5 | 43 ± 5 | 17 ± 3 | 40 ± 3 | |
| NACs | 26 ± 3 | 16 ± 2 | 117 ± 8 | 61 ± 6* | 29 ± 3 | 99 ± 10 |
| 16 ± 1 | 10 ± 1 | 74 ± 2 | 32 ± 1 | 15 ± 1 | 53 ± 1 | |
| NACc | 3.2 ± 0.7 | 1.3 ± 0.5 | 47 ± 5 | 2.5 ± 0.8 | 0.7 ± 0.5 | 3.3 ± 1 |
| 5 ± 1 | 2 ± 1 | 93 ± 2 | 50 ± 10 | 4 ± 3 | 46 ± 10 | |
| BNST | 15 ± 1.5 | 12 ± 1.5 | 66 ± 5 | 37 ± 6 | 18 ± 2.5 | 54 ± 6 |
| 15 ± 1 | 12 ± 1 | 73 ± 2 | 33 ± 2 | 17 ± 1.4 | 50 ± 2 | |
| CeA | 56 ± 6*** | 28 ± 3 | 180 ± 13 | 95 ± 10 | 69 ± 6 | 232 ± 21 |
| 20 ± 1.5 | 10 ± 1 | 70 ± 2 | 23 ± 1 | 18 ± 1 | 59 ± 1 | |
| BLA | 55 ± 7 | 40 ± 10 | 140 ± 10 | 90 ± 8 | 66 ± 5 | 217 ± 19 |
| 22 ± 1 | 15 ± 2 | 63 ± 2 | 24 ± 0.6 | 18 ± 0.5 | 58 ± 0.7 | |
| HIP | 33 ± 4 | 20 ± 2.5 | 92 ± 7.5 | 17 ± 2 | 17 ± 2 | 50 ± 5 |
| 21 ± 1 | 14 ± 1 | 65 ± 1 | 20 ± 1 | 20 ± 1.5 | 60 ± 2 | |
| VTA | 0.55 ± 0.19 | 0.07 ± 0.03 | 0.66 ± 0.15 | 160 ± 11 | 152 ± 10 | 529 ± 43 |
| 32 ± 6 | 6 ± 3 | 62 ± 6 | 19 ± 0.7 | 19 ± 0.7 | 62 ± 0.8 | |
Data in italic are expressed as mean and SEM in % of total excitatory or inhibitory triads
* p < 0.05; *** p < 0.001, as compared to SYNSERT+ boutons apposed to the postsynaptic component by two-way ANOVA analysis of variance followed by Bonferroni post hoc comparisons. An overall interaction was observed between both factors “brain region × pre/post/equidistant location of triads”, F(14, 464) = 62.87, p < 0.0001, with a main effect of each factor “brain region”, F(7, 232) = 75.32, p < 0.0001 and “pre/post/equidistant location of triads’’, F(2, 464) = 423.2, p < 0.0001