Table 3.
Podometric values for stages of glomerular development
| Immature stage | Mature stage <38 weeks | Mature stage ≥38 weeks | |
|---|---|---|---|
| Glomerular volume (μm3 x 106) | 0.13 ± 0.07 | 0.35 ± 0.08 | 0.60 ± 0.19 |
| (0.03–0.24) | (0.26–0.50) | (0.28–0.90) | |
| Podocyte number per glomerulus | 326 ± 154 | 584 ± 131 | 589 ± 166 |
| (71–549) | (406-850) | (393–1048) | |
| Podocyte density (per 106 μm3) | 2,702 ± 451 | 1,870 ± 250 | 1,166 ± 310 |
| (1,731–3,649) | (1,375-2,253) | (696–1732) | |
| Total podocyte volume (x103 μm3) | 41.5 ± 23.4 | 136.0 ± 45.3 | 195.1 ± 81.7 |
| (8.2–80.8) | (86.8–260.0 | (64.1–320.8) | |
| Average podocyte volume (μm3) | 131 ± 36 | 233 ± 64 | 335 ± 136 |
| (76–215) | (143–397) | (122–583) |
“Immature stage” of development is at the pre-capillary loop stage. “Mature <38 weeks” includes all glomeruli at the capillary loop and later stages of development in kidneys before 38 weeks’ gestation. “Mature stage >38 weeks” includes all glomeruli at the capillary loop and later stages of development in kidneys at ≥38 weeks’ gestation. Values are mean ± SD with the range shown in parentheses. Total podocyte volume is the GLEPP1-positive area multiplied by the glomerular volume to give an estimate for the average volume of all podocytes present in glomeruli