Table 4.

Methylmalonic aciduria and homocystinuria, cobalamin C (cblC) complementation type (MMACHC): general, renal, and extrarenal characteristics

Manifestation data
Onset of disease
Infantile onset	44 %, (n = 16/36)
Noninfantile onset	56 %, (n = 20/36)
Characteristics of renal disease
Proteinuria and hematuria	100 %, (n = 27/27)
Hemolytic uremic syndrome	66 %, (n = 24/36)
Normotensive	10 %, (n = 2/20)
Hypertensive	90 %, (n = 18/20)
Nephrotic syndrome	11 %, (n = 3/27)
Chronic kidney disease (CKD) 1	11 %, (n = 4)
CKD 2–5	89 %, (n =32)
Dialysis	22 %, ( n = 8)
Kidney transplant	6 %, (n = 2)
Extrarenal manifestations
Neurological impairment	44 %, (n = 16/36)
Cardiopulmonary involvement	39 %, (n = 14/36)
Pulmonary hypertension	17 %, (n = 6/36)