Fig. 6.

Subtle changes detected in light-induced anxiety and prepulse inhibition in Kiaa0319 mutant mice. a–c Anxiety related behaviour measured in the light/dark box over the full 10 min duration of the test (a), in the initial 5 min of the light/dark box test (b) and in the elevated plus maze (EPM) (c) of Kiaa0319 +/+ (n = 16; 17 for EPM), +/− (n = 17) and −/− (n = 14) mice. Kiaa0319 −/− mice display reduced anxiety in the first 5 min of the light/dark box test when compared with +/+ and +/− animals. No significant difference in anxiety is observed between genotypes in the EPM. Light–dark ratio ratio of time spent in the dark vs time spent in the light. Post hoc statistically significant Bonferroni LSD results, *p ≤ 0.01, **p ≤ 0.001. d–e Prepulse inhibition/facilitation of the acoustic startle response in male (d) and female (e) Kiaa0319 +/+ (male = 7, female = 7), +/− (male = 8, female = 4) and −/− (male = 7, female = 6) mice. Homozygous mutant (−/−) males show a deficit in prepulse facilitation at 400- and 800-ms gaps between prepulse and pulse compared with the other two genotypes. Post hoc statistically significant Bonferroni LSD results: homozygous (−/−) vs heterozygous (+/−) or wild-type (+/+), **p ≤ 0.001. The data represent mean ± SEM