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. 2017 Mar 28;7:98. doi: 10.3389/fcimb.2017.00098

Figure 4.

Figure 4

Induction of Tim-3 expression on T cells within PBMCs by common γ-chain (γc) cytokines (IL-2, IL-7, IL-15) could not be abrogated in the presence of anti-common γc receptor neutralizing antibody compared with no antibody treatments. PBMCs were selected from 8 of AsC and 8 of CHB patients, which were used in the experiments of Figure 1 but did not overlap with the patients from Figures 2, 3. (A) Comparison of frequencies for CD4+Tim-3+ cells in response to γc cytokines stimulation with or without neutralizing antibody in AsC. (B) Comparison of frequencies for CD4+Tim-3+ cells in response to γc cytokines stimulation with or without neutralizing antibody in CHB. (C) Comparison of frequencies for CD8+Tim-3+ cells in response to γc cytokines stimulation with or without neutralizing antibody in AsC. (D) Comparison of frequencies for CD8+Tim-3+ cells in response to γc cytokines stimulation with or without neutralizing antibody in CHB. Data were presented as mean and standard deviation. Mann-Whitney test was used for comparison between groups. #P > 0.05.