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. 2017 Mar 28;7:96. doi: 10.3389/fcimb.2017.00096

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Copyright © 2017 Ziveri, Barel and Charbit.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic depiction of the Francisella glycolytic and gluconeogenic pathways. F. tularensis possesses a complete glycolysis and gluconeogenesis pathways as well as an intact TCA cycle. In contrast, it lacks a functional Entner-Doudoroff (ED) pathway and the oxidative branch of the Pentose phosphate pathway (PPP), in red-dotted arrows. PPP^*, the non-oxidative branch of the PPP is still functional. Ppdk and FBPase (in red) represent only two enzymatic steps specifically acting in the gluconeogenic direction. The dotted green arrows indicate the non-oxidative part of the Pentose Phosphate Pathway. Gene numbers in F. novicida: pgm (FTN_0514); pgi (FTN_0663); gpml (FTN_0648); eno (FTN_0621); glpX (FTN_0298); pfk (FTN_1210); (FTN_1631); glpD (FTN_1584); glpK (FTN_1585). x^ess, essential genes. ^*Expression of fba and pgK have shown to be up-regulated in BMM (Wehrly et al., 2009). F. tularensis Schu S4 and F. novicida U112 are able to ferment glycerol but the enzymes involved are unknown. F. tularensis LVS is unable to ferment glycerol. DHAP, Dihydroxyacetone phosphate (or Glycerone-Phosphate); GAP, glyceraldehyde 3-phosphate; PEP, phosphoenolpyruvate.