Table 2.

Histopathological analysis of organs from hamsters experimentally infected with Leptospira.

Organ	Days post-infection	Histopathological observation
Lung	0	Discrete congestion
	3	Congestion, discrete widened alveolar septa
	6	Congestion, discrete hemorrhage, widened alveolar septa, proliferation of bronchial epithelium
	8	Congestion, multiple foci of widened alveolar septa, hemorrhage
	9	Discrete congestion, diffuse widened alveolar septa (interstitial pneumonia), proliferation of bronchial epithelium
	10	Congestion, intense hemorrhage, interstitial pneumonia, hyperplasia, hypertrophy of bronchial epithelium
	10 (ni)	Discrete congestion
Kidney	0	Discrete congestion
	3	Discrete congestion
	6	Congestion, discrete hemorrhage
	8	Congestion, hemorrhage, foci of nephrosis, and tubular necrosis
	9	Intense congestion, intense hemorrhage, nephrosis, and tubular necrosis
	10	Intense congestion, intense hemorrhage, intense tubular necrosis
	10 (ni)	Discrete congestion
Liver	0	Discrete congestion
	3	Discrete focal and periportal hepatitis
	6	Congestion, discrete hemorrhage, cytoplasmic rarefaction in hepatocytes
	8	Congestion, foci of hepatitis, vacuolar degeneration, degradation of trabecular architecture, discrete hepatocyte necrosis
	9	Congestion, hemorrhage, degradation of trabecular architecture, focal hepatitis
	10	Congestion, focal and periportal hepatitis, hepatocyte cytoplasmic rarefaction
	10 (ni)	Discrete congestion

The animals were infected with a lethal dose of L. interrogans serovar Kennewicki strain Pomona Fromm (LPF). After 0, 3, 6, 8, 9, or 10 days post-infection, the animals were euthanized and the lungs, kidneys, and livers were removed and prepared for histopathology by H-E staining. Organs from non-infected (ni) hamsters were used as controls.