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. 2017 Mar 28;8:535. doi: 10.3389/fmicb.2017.00535

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Copyright © 2017 Joffe, Schneider, Lopes, Azevedo, Staats, Kmetzsch, Schrank, Del Poeta, Vainstein and Rodrigues.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of mebendazole on cryptococcal biofilms. Biofilm formation and mature biofilm activity were measured indirectly by XTT reduction assay. (A) Incubation of C. neformans with mebendazole before biofilm formation. (B) Treatment of mature biofilms with mebendazole. AmB, amphotericin B (2 μg/ml); Fluco, fluconazole (8 μg/ml). Statistical significances after comparison with control systems are indicated by asterisks (P < 0.0001). Data illustrate a representative experiment of three independent replicates.