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Impact of the association of mebendazole with amphotericin B (AmB) or fluconazole (FLC) on antifungal activity.
| Drug A | Drug B | FIC∗ | ||||
|---|---|---|---|---|---|---|
| MIC Alone (μg/ml) | MIC Combined (μg/ml) | MIC Alone (μg/ml) | MIC Combined (μg/ml) | |||
| Mebendazole | 0.095 | 0.0475 | AmB | 0.25 | 0.125 | 1 |
| Mebendazole | 0.095 | 0.0475 | Fluconazole | 2 | 2 | 1.5 |
∗Fractional inhibitory concentration index (FIC); Strongly synergistic: FIC < 0.5; Synergistic: FIC < 1; Additive: FIC = 1; No effect: 1 < FIC < 2; Antagonistic: FIC > 2.
