Table 1.

Examples of On-Target, Off-Tumor Toxicities of CAR T Cell Therapies

Target Antigen	Disease	On-Target, Off-Tumor Toxicity	References
CD19	B cell malignancies	B cell aplasia	Maude et al.50
			Porter et al.51
HER2/ERBB2	colon cancer	lethal pulmonary failure	Morgan et al.16
Carbonic anhydrase-IX (CA-IX)	renal cancer	bile duct epithelium infiltration (cholestasis)	Lamers et al.52
			Lamers et al.53
CD30	Hodgkin’s lymphoma	lymph node, tonsils, thymus infiltration	Wang et al.54
CD123	acute myeloid leukemia	elimination of hematopoietic stem cell and myeloid compartments	Mardiros et al.55
			Gill et al.56
Kappa light chain	non-Hodgkin’s lymphoma/multiple myeloma	elimination of kappa-expressing B and plasma cells	Ramos et al.57