TABLE 3.
Selected plasma amino acid clearances of mice fed diets with various levels of supplemental arginine or citrulline for 2 wk1
| Treatment diets |
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| Arginine-supplemented |
Citrulline-supplemented |
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| Clearance rate, L · kg−1 · h−1 | Control | A1 | A3 | A5 | C1 | C3 | C5 | PArg | PCit | PCit-Arg2 |
| n | 9 | 7 | 7 | 9 | 9 | 6 | 7 | |||
| Arginine | 6.0 ± 0.2 | 4.9 ± 0.4 | 4.5 ± 0.4 | 5.4 ± 0.5 | 4.7 ± 0.4 | 4.8 ± 0.3 | 4.1 ± 0.3 | 0.44 | 0.012 | 0.21 |
| Citrulline | 1.6 ± 0.1 | 1.5 ± 0.1 | 1.5 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.7 ± 0.1 | 1.8 ± 0.1 | 0.66 | 0.18 | 0.42 |
| Ornithine | 2.6 ± 0.1 | 1.9 ± 0.2 | 2.2 ± 0.5 | 2.0 ± 0.3 | 1.9 ± 0.2 | 1.8 ± 0.2 | 2.1 ± 0.4 | 0.39 | 0.09 | 0.58 |
| Phenylalanine | 2.8 ± 0.1 | 2.7 ± 0.1 | 2.3 ± 0.2 | 2.5 ± 0.2 | 2.4 ± 0.2 | 2.8 ± 0.2 | 2.5 ± 0.1 | 0.09 | 0.86 | 0.39 |
| Tyrosine | 3.8 ± 0.2 | 4.0 ± 0.3 | 3.4 ± 0.2 | 3.6 ± 0.3 | 3.4 ± 0.3 | 3.7 ± 0.4 | 3.3 ± 0.4 | 0.16 | 0.71 | 0.63 |
1
Values are means ± SEMs. Control, 75 μmol arginine · kg−1 · h−1; A1, A3, and A5 provided 75, 225, and 375 μmol supplemental arginine · kg−1 · h−1, respectively; C1, C3, and C5 provided 75, 225, and 375 μmol supplemental citrulline · kg−1 · h−1, respectively.
2
Comparison between citrulline and arginine; slopes differed for P < 0.05.