TABLE 3.
Estimate of the acute effects of supplementation on thiamin, riboflavin, and vitamins B-6 and A in fasting milk samples collected from healthy Bangladeshi women who consumed 1 (day 2) and 2 (day 3) capsules of the micronutrient supplement1
| Thiamin | Riboflavin | Vitamin B-6 | Vitamin A | |
| Day, μg/L | ||||
| 1 | 137 (108, 179)2 | 34.3 (17, 56) | 86.9 (54, 117) | 532 (353, 829) |
| 2 | 160 (113, 185) | 45.1 (26, 80) | 126 (80, 191) | 566 (409, 897) |
| 3 | 166 (131, 199) | 64.7 (33, 113) | 214 (146, 281) | 651 (466, 930) |
| Increase, μg/L | ||||
| On day 2 | 22.6 | 10.8 | 39.3 | 34.0 |
| On day 3 vs. day 2 | 6.0 | 19.6 | 87.5 | 84.7 |
| On day 3 vs. day 1 | 28.6 | 30.4 | 127 | 119 |
| Increase based on infant intake (0.78 L/d), μg/d | ||||
| On day 2 | 17.7 | 8.4 | 30.7 | 26.5 |
| On day 3 vs. day 2 | 4.6 | 15.3 | 68.3 | 66.1 |
| On day 3 vs. day 1 | 22.3 | 23.7 | 98.9 | 92.6 |
| Supplemental amount received, mg | ||||
| Day 2 | 5 | 1.4 | 3 | 0.56 |
| Day 3 vs. day 2 | 10 | 2.8 | 6 | 1.1 |
| Day 3 vs. day 1 | 15 | 4.2 | 9 | 1.7 |
| Supplement secreted into breast milk,3 % | ||||
| Day 2 | 0.35 | 0.60 | 1.0 | 4.7 |
| Day 3 vs. day 2 | 0.05 | 0.54 | 1.1 | 6.0 |
| Day 3 vs. day 1 | 0.14 | 0.56 | 1.1 | 5.5 |
| Supplement amount received,4 % of Adequate Intake | ||||
| Adequate Intake for infants aged 0–6 mo, μg/d | 200 | 300 | 100 | 400 |
| Day 2, % of Adequate Intake | 8.8 | 2.8 | 30.7 | 6.6 |
| Day 3 vs. day 2, % | 2.3 | 5.1 | 68.3 | 16.6 |
| Day 3 vs. day 1, % | 11.1 | 7.9 | 98.9 | 23.2 |
| Median maximum concentration,5 μg/L | ||||
| Day 1 | 169 | 58.1 | 118 | 711 |
| Day 2 | 187 | 99.1 | 162 | 1117 |
| Day 3 | 211 | 438 | 449 | 1142 |
| Amounts provided at maximum,6 μg/feeding (% of Adequate Intake) | ||||
| Day 1 | 13.2 (6.6) | 4.5 (1.5) | 9.2 (9.2) | 55.4 (13.9) |
| Day 2 | 14.6 (7.3) | 7.7 (4.7) | 12.6 (12.6) | 87.1 (21.8) |
| Day 3 | 16.4 (8.2) | 34.2 (11.4) | 35.0 (35.0) | 89.1 (22.3) |
n = 18. Samples were obtained from milk aliquot III collected from healthy Bangladeshi mothers at 2–4 mo of lactation.
Median; IQR in parentheses (all such values).
Increase based on infant intake compared with the supplemental amount received.
Highest median concentration measured at any given time interval within a day.
Estimated amount of vitamin in a single feeding at maximum median concentrations based on an average of 10 feedings/d and 780 mL daily consumption = 78 mL, presented as micrograms per feeding (% of Adequate Intake).