TABLE 1.
Intravenous infusion rates of the different tracers in humans, pigs, rats, and mice1
| Species, μmol ⋅ kg−1 ⋅ h−1 |
||||
| Humans | Pigs | Rats | Mice | |
| Tracer validation | ||||
| l-2,3,3,4,4-[2H5]-glutamine | — | — | — | 156.0 |
| l-U-[13C5]-glutamine | — | — | — | 156.0 |
| U-[13C6]-glucose | — | — | — | 690.0 |
| Main study | ||||
| l-2,3,3,4,4-[2H5]-glutamine | 6.0 | 16.1 | 128.0 | 156.0 |
| l-2-[15N]-glutamine | 15.0 | 37.1 | 128.0 | 156.0 |
| l-5,5-[2H2]-citrulline | 0.5 | 1.2 | 5.0 | 7.0 |
1
Stable isotopes were purchased from Cambridge Isotopic Laboratories. The priming dose was the equivalent to a 1-h infusion.