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. 2017 Feb 22;147(4):556–562. doi: 10.3945/jn.116.243832

TABLE 2.

Associations between plasma zinc and FIB-4 at baseline and longitudinally in the entire cohort and separated by sex among HIV-monoinfected and HIV/HCV-coinfected groups1

Entire cohort
 Women
 Men
Baseline multivariate analysis2
 Longitudinal multivariate3 analysis
 Baseline multivariate analysis4
 Longitudinal multivariate analysis5
 Baseline multivariate analysis4
 Longitudinal multivariate analysis5
β P β P β P β P β P β P
Cohort
 Zinc, mg/L −0.63 ± 0.25 0.011 −0.37 ± 0.17 0.033 −0.53 ± 0.27 0.054 −0.24 ± 0.16 0.126 −0.76 ± 0.35 0.033 −0.43 ± 0.24 0.073
 Zinc deficiency6 −0.44 ± 0.14 0.002 0.38 ± 0.12 0.001 −0.34 ± 0.16 0.043 0.08 ± 0.10 0.002 −0.53 ± 0.20 0.008 0.52 ± 0.17 0.002
HIV monoinfected
 Zinc, mg/L −0.01 ± 0.202 0.98 −0.06 ± 0.16 0.70 −0.06 ± 0.17 0.72 −0.11 ± 0.10 0.29 0.05 ± 0.29 0.87 −0.07 ± 0.22 0.76
 Zinc deficiency6 −0.01 ± 0.125 0.97 0.27 ± 0.13 0.038 −0.01 ± 0.11 0.96 0.07 ± 0.07 0.34 −0.02 ± 0.18 0.93 0.33 ± 0.18 0.066
HIV/HCV coinfected
 Zinc, mg/L −2.38 ± 0.72 0.001 −1.79 ± 0.58 0.003 −1.17 ± 0.82 0.16 −0.36 ± 0.56 0.53 −3.62 ± 1.17 0.003 −3.23 ± 0.94 0.001
 Zinc deficiency6 −0.70 ± 0.32 0.031 0.53 ± 0.26 0.045 −0.44 ± 0.38 0.25 −0.03 ± 0.25 0.92 −0.84 ± 0.48 0.086 0.90 ± 0.42 0.036
1

Values are means ± SEs, n = 487. FIB-4 was calculated with the use of the following formula: [age (years) × AST (U/L)]/[PLT (109 cells/L) × ALT1/2(U/L)]. ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUDIT, Adult Use Disorders Identification Test; FIB-4, fibrosis-4; HCV, hepatitis C virus; PLT, platelet count.

2

Analyses conducted with the use of linear and logistic regression. All models were adjusted for sex, race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

3

Analysis conducted with the use of mixed models. All models were adjusted for sex, race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

4

Analyses conducted with the use of linear and logistic regression. All models were adjusted for race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

5

Analysis conducted with the use of mixed models. All models were adjusted for race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

6

Defined as plasma zinc concentration <0.75 mg/L.