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. 2017 Feb 22;147(4):556–562. doi: 10.3945/jn.116.243832

TABLE 3.

Associations between plasma zinc and mtDNA 8-oxo-dG at baseline and longitudinally in the entire cohort and separated by sex among HIV-monoinfected and HIV/HCV-coinfected groups1

Entire cohort
 Women
 Men
Baseline multivariate analysis2
 Longitudinal multivariate analysis3
 Baseline multivariate analysis4
 Longitudinal multivariate analysis5,6
 Baseline multivariate analysis4
 Longitudinal multivariate analysis5,7
β P β P β P β P β P β P
Cohort
 Zinc, mg/L −0.20 ± 0.05 <0.001 −0.04 ± 0.03 0.12 −0.14 ± 0.09 0.11 −0.06 ± 0.06 0.37 −0.21 ± 0.07 0.003 −0.03 ± 0.03 0.22
 Zinc deficiency8 −0.09 ± 0.03 0.011 0.05 ± 0.02 0.044 −0.05 ± 0.06 0.34 0.05 ± 0.04 0.27 −0.11 ± 0.04 0.017 0.04 ± 0.03 0.16
HIV monoinfected
 Zinc, mg/L −0.12 ± 0.05 0.009 −0.03 ± 0.03 0.19 −0.11 ± 0.08 0.15 −0.05 ± 0.06 0.44 −0.12 ± 0.06 0.037 −0.03 ± 0.03 0.32
 Zinc deficiency8 −0.05 ± 0.03 0.08 0.03 ± 0.02 0.20 −0.03 ± 0.05 0.53 0.03 ± 0.04 0.47 −0.06 ± 0.04 0.11 0.02 ± 0.03 0.34
HIV/HCV coinfected
 Zinc, mg/L −0.53 ± 0.30 0.08 −0.15 ± 0.11 0.16 −0.07 ± 0.41 0.87 — — −1.11 ± 0.49 0.037 −0.47 ± 0.21 0.032
 Zinc deficiency8 −0.13 ± 0.13 0.32 0.04 ± 0.05 0.44 −0.18 ± 0.20 0.37 — — −0.18 ± 0.20 0.37 — —
1

Values are means ± SEs, n = 487. AUDIT, Adult Use Disorders Identification Test; HCV, hepatitis C virus; mtDNA, mitochondrial DNA; 8-oxo-dG, 8-hydroxyguanosine.

2

Analyses conducted with the use of linear and logistic regression. All models were adjusted for sex, race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

3

Analysis conducted with the use of mixed models. All models were adjusted for sex, race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

4

Analyses conducted with the use of linear and logistic regression. All models were adjusted for race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

5

Analysis conducted with the use of mixed models. All models were adjusted for race, BMI, CD4 cell count, HIV viral load, AUDIT, and tobacco use.

6

Because of small sample size, longitudinal models in women in the HIV/HCV group did not converge.

7

Because of small sample size, longitudinal models in men in the HIV/HCV group with zinc deficiency did not converge.

8

Defined as plasma zinc concentration <0.75 mg/L.