Table 3. Univariate analysis of clinicopathological features and biomarkers with respect to ERα status.
| Feature | Whole cohort (n = 446) | ERα+ cases (n = 375) | ||||||
|---|---|---|---|---|---|---|---|---|
| OS | DFS | OS | DFS | |||||
| HR (CI) | P-value | HR (CI) | P-value | HR (CI) | P-value | HR (CI) | P-value | |
| Grade | 1.59 (1.01–2.51) | 0.05 | 0.89 (0.48–1.66) | 0.71 | 1.09 (0.73–1.61) | 0.68 | 0.87 (0.55–1.37) | 0.55 |
| Age | 1.05 (1.03–1.08) | 0.00001 | 1.04 (1.01–1.07) | 0.01 | 1.07 (1.04–1.10) | 0.000002 | 1.05 (1.01–1.08) | 0.004 |
| Node positive | 1.24 (0.75–2.08) | 0.39 | 1.91 (1.03–3.53) | 0.04 | 1.17 (0.68–2.01) | 0.58 | 2.72 (1.30–5.69) | 0.008 |
| Size (>20 mm) | 1.36 (0.75–2.47) | 0.31 | 1.05 (0.34–2.54) | 0.92 | 1.27 (0.69–2.33) | 0.45 | 1.01 (0.41–2.48) | 0.99 |
| ER | 1.00 (0.48–2.12) | 0.99 | 1.12 (0.15–8.22) | 0.91 | ||||
| AR | 0.86 (0.52–1.41) | 0.55 | 0.39 (0.12–0.79) | 0.009 | 0.84 (0.47–1.50) | 0.57 | 0.30 (0.15–0.65) | 0.002 |
| ERβ1 | 1.15 (0.59–2.25) | 0.68 | 0.91 (0.38–2.16) | 0.82 | 0.87 (0.44–1.71) | 0.69 | 0.91 (0.38–2.16) | 0.83 |
| ERβ2 | 1.14 (0.58–2.22) | 0.71 | 1.40 (0.50–3.95) | 0.52 | 1.25 (0.60–2.62) | 0.56 | 1.37 (0.49–3.87) | 0.55 |
| ERβ5 | 0.91 (0.42–2.00) | 0.82 | 0.38 (0.11–1.29) | 0.12 | 2.39 (0.55–10.30) | 0.24 | 0.38 (0.11–1.33) | 0.13 |
| FOXA1 | 0.75 (0.42–1.34) | 0.33 | 0.41 (0.22–0.77) | 0.005 | 0.55 (0.28–0.98) | 0.044 | 0.45 (0.22–0.94) | 0.033 |
| PR | 1.01 (0.57–1.81) | 0.96 | 0.97 (0.43–2.19) | 0.94 | 1.13 (0.57–2.26) | 0.72 | 0.94 (0.39–2.24) | 0.89 |
| Survivin (nuclear) | 1.07 (0.67–1.72) | 0.782 | 0.96 (0.52–1.77) | 0.89 | 1.05 (0.64–1.72) | 0.86 | 1.03 (0.54–1.98) | 0.93 |
| Survivin (cytoplasmic) | 0.76 (0.36–1.59) | 0.47 | 0.61 (0.26–1.46) | 0.27 | 0.48 (0.20–1.11) | 0.07 | 0.55 (0.19–1.57) | 0.26 |
| Ki67 | 1.21 (0.72–2.04) | 0.46 | 0.56 (0.27–1.17) | 0.12 | 1.00 (0.57–1.86) | 0.99 | 0.61 (0.28–1.30) | 0.20 |
| E-cadherin | 1.56 (0.82–2.97) | 0.18 | 0.54 (0.26–1.15) | 0.11 | 1.47 (0.75–2.89) | 0.26 | 0.54 (0.27–1.15) | 0.11 |
| Bcl-2 | 1.13 (0.41–3.12) | 0.81 | 1.02 (0.31–3.38) | 0.97 | 1.04 (0.33–3.35) | 0.94 | 1.00 (0.30–3.33) | 0.99 |
| Prolactin | 0.98 (0.61–1.59) | 0.95 | 1.04 (0.57–1.88) | 0.90 | 0.99 (0.60–1.65) | 0.99 | 0.93 (0.49–1.79) | 0.84 |
| HER2 | 1.82 (0.25–13.22) | 0.56 | 1.25 (0.30–5.27) | 0.76 | 27.32 (3.19–233.88) | 0.003 | 5.09 (0.63–41.40) | 0.13 |
| p53 | 0.97 (0.52–1.81) | 0.91 | 0.45 (0.17–1.14) | 0.09 | 0.95 (0.49–1.82) | 0.87 | 0.45 (0.17–1.15) | 0.09 |
| AR+ FOXA1+ | 0.76 (0.35–1.62) | 0.43 | 0.41 (0.16–1.09) | 0.08 | 0.44 (0.19–1.05) | 0.06 | 0.30 (0.10–0.88) | 0.03 |
| ERβ1+ FOXA1+ | 22.09 (0.04–11424)) | 0.33 | 1.31 (0.17–9.76) | 0.79 | 20.86 (0.001–604504) | 0.56 | 0.88 (0.21–3.83) | 0.87 |
| ERβ2+ FOXA1+ | 22.22 (0.06–7823) | 0.30 | 21.84 (0.004–13372) | 0.48 | 21.11 (0.005–82754) | 0.47 | 21.84 (0.004–133724) | 0.49 |
| ERβ5+, FOXA1+ | 0.31 (0.09–1.06) | 0.06 | 0.11 (0.02–0.68) | 0.02 | 0.24 (0.05–1.01) | 0.05 | 0.11 (0.02–0.68) | 0.02 |
Significant P values are in bold. HR = hazard ratio, CI = confidence intervals.