Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
PHD2 inhibits HIF-1α which in turn inhibits PHD3 expression. In the absence of PHD2, HIF-1α translocates from the cytoplasm to the nucleus, binds to the hypoxia response element (HRE), and activates genes required for chondrocyte hypertrophy. In the presence of PHD2, HIF-1α undergoes prolyl hydroxylation and subsequent proteosomal degradation, and therefore, chondrocyte hypertrophy is reduced.
