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. 2017 Mar 28;7:45645. doi: 10.1038/srep45645

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Copyright © 2017, The Author(s)

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(A) tdTomato visualization of NCC in the small intestine and colon shows delayed colonization of the colon in EdnrB^NCC−/− animals compared to EdnrB^NCC+/−, with the migratory wavefront of NCC marked by white arrows at E14.5. (B) Aganglionosis in the distal colon of EdnrB^NCC−/− animals at P21 causes functional obstruction (marked by white arrowhead). Normal, pelleted stool is seen in the distal EdnrB^NCC+/− colon. (C) Reduced splenic size of EdnrB^NCC−/− compared to EdnrB^NCC+/− animals at P21. (D) tdTomato expressing NCC in EdnrB^NCC+/− and EdnrB^NCC−/− spleens at P21. (E) Spleens were harvested from EdnrB^NCC+/− and EdnrB^NCC−/− animals at P0, P9 and P18 and weighed. (*p < 0.05). Scale bars: A 400 μm, B 1 cm, C 4 mm and D 100 μm.