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. 2017 Feb 10;80(3):740–755. doi: 10.1021/acs.jnatprod.6b00970

Table 3. Inhibitory Data for Compounds on MetAP Enzyme Activity and Cell Proliferation Potencies Against Cancer Cell Lines.

	IC₅₀ (μM)		IC₅₀ (nM)
compound	MetAp1	MetAp2	MDA-MB-435	HCT-116
BGM-A^53,54	0.7⁵⁴/2⁵³	0.4⁵⁴/11⁵³	1^1e,35	0.4,⁵³ 16^1e
BGM-O⁵³	3⁵³	>50⁵³	0.3^1e	0.8⁵³
LAF389	0.7⁵⁴	0.4⁵⁴	40³⁵	40⁵⁴
LBM648	>10⁵⁴	0.4⁵⁴		140⁵⁴
benzLAF389			3.8³⁸	44³⁸
FMG		0.2⁵⁸	54 (MB-231)⁴⁴
IV-43	0.4⁴⁹/1.5⁶¹	–⁵⁸/>300⁶¹		300 (HT1080)⁶¹
PZQ	0.1⁴⁹	>100⁴⁹