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. 2017 Mar 27;17:40. doi: 10.1186/s12935-017-0410-1

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Dose-response curves of DDP, TET and the combination treatment. Cisplatin-resistant (a) and cisplatin-sensitive (b) A549 cells were treated with different concentrations of the two drugs (TET: 0.5–8 µg/ml; DDP: 6.25–100 µM) for 48 h. The concentration of TET in the combination treatment was 0.25 µg/ml. C and D are the IC₅₀ values of DDP and combination treatment. *p < 0.05 versus the DDP treatment (n = 3)