Figure 2.

High throughput screening identifies protein synthesis inhibitors. Raw data of luciferase activity are plotted over the 1,158 compounds tested. Structures of selected hits (colored dots) are shown below. Red dots show compounds (gray boxes) that resemble the antibiotics erythromycin (left) and chloramphenicol (middle). The green box (right) identifies T6102 with a structure unlike any known class of translation inhibitors.