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. 2017 Mar 28;7:45396. doi: 10.1038/srep45396

Table 1. Intra- and inter-observer variability of CCIC method analyzed by Bland-Altman plots with mean difference and level of agreement (LoA).

DRG Observer 1 Observer 2 P Mean bias (95% CI)
Mean (SD) Mean (SD) (Two-sided)
Inter-observer variability
1 12.18 (12.21) 11.82 (11.97) 0.371 0.36 (−2.157 to 2.885)
2 7.091 (6.534) 7.182 (6.615) 0.67 −0.09 (−1.46 to 1.28)
3 31.09 (7.867) 28.82 (7.167) <0.001 2.27 (0.11 to 4.43)
4 30.82 (24.71) 29.64 (23.75) 0.01 1.18 (−1.27 to 3.63)
5 58.00 (38.60) 55.36 (37.27) 0.01 2.63 (−1.77 to 7.04);
6 46.18 (17.39) 43.73 (15.82) 0.02 2.46 (−3.05 to 7.95)
7 50.09 (37.43) 47.27 (34.94) <0.01 2.82 (−2.50 to 8.14)
8 11.45 (12.32) 10.82 (10.59) 0.36 0.64 (−3.68 to 4.96)
9 12.73 (18.52) 12.64 (17.99) 0.80 0.09 (−2.14 to 2.32)
10 31.36 (22.82) 31.36 (22.82) 1.0 0.00 (−2.32 to 2.32)
11 23.00 (27.01) 21.36 (25.55) 0.01 1.64 (−1.68 to 4.95)
12 9.909 (7.231) 9.727 (6.944) 0.62 0.18 (−2.11 to 2.47)
Intra-observer 1 variability
DRG First Analysis Second Analysis P Mean bias (95% CI)
Mean (SD) Mean (SD) (Two-sided)
1 12.18 (12.21) 12.18 (12.15) 1.0 0.00 (−1.24 to 1.24)
2 7.091 (6.534) 6.909 (6.457) 0.17 0.18 (−0.61 to 0.97
3 31.09 (7.867) 30.27 (6.987) 0.04 0.82 (−1.47 to 3.11)
4 30.82 (24.71) 30.0 (24.12) 0.03 0.82 (−1.30 to 2.93)
5 58.00 (38.60) 57.27 (37.80) 0.02 0.73 (−2.56 to 4.02)
6 46.18 (17.39) 44.27 (16.40) 0.01 1.91 (−1.65 to 5.47)
7 50.09 (37.43) 48.36 (36.66) 0.04 1.73 (−2.84 to 6.29)
8 11.45 (12.32) 11.00 (11.78) 0.10 0.45 (−1.15 to 2.06)
9 12.73 (18.52) 12.18 (17.09) 0.34 0.55 (−3.00 to 4.09)
10 31.36 (22.82) 31.64 (23.05) 0.57 −0.27 (−3.30 to 2.78)
11 23.00 (27.01) 22.27 (26.35) 0.07 0.73 (−1.61 to 3.06)
12 9.909 (7.231) 9.727 (6.944) 0.34 0.18 (−1.00 to 1.36)
Intra-observer 2 variability
DRG First Analysis Second Analysis P Mean bias (95% CI)
Mean (SD) Mean (SD) (Two-sided)
1 11.82 (11.97) 11.64 (12.02) 0.5 0.18 (−1.53 to 1.90)
2 7.182 (6.615) 7.091 (6.441) 0.77 0.09 (−2.14 to 2.31)
3 28.82 (7.167) 27.36 (7.366) 0.04 1.46 (−2.60 to 5.50)
4 29.64 (23.75) 29.09 (23.41) 0.11 0.55 (−1.49 to 2.58)
5 55.36 (37.27) 54.91 (36.50) 0.48 0.45 (−3.60 to 4.51)
6 43.73 (15.82) 43.36 (15.81) 0.44 0.36 (−2.58 to 3.30)
7 47.27 (34.94) 46.36 (34.21) 0.13 0.91 (−2.65 to 4.47)
8 10.82 (10.59) 10.64 (11.08) 0.5 0.18 (−1.53 to 1.90)
9 12.64 (17.99) 12.55 (17.87) 0.72 0.09 (−1.54 to 1.72)
10 31.36 (22.82) 30.55 (21.83) 0.15 0.82 (−2.56 to 4.19)
11 21.36 (25.55) 20.73 (24.19) 0.39 0.64 (−3.94 to 5.20)
12 9.727 (6.944) 9.818 (7.097) 0.76 −0.09 (−1.94 to 1.76)

Note: P values were calculated by 2-sided paired t-test. Limits of agreement were set as mean difference ±1.96 × SD. Upper and lower limits of agreement indicate 95% confidence range.