Table 2.

Performance of serum prostate-specific antigen-based models for predicting cancer and high-grade cancer on biopsy (Adapted from [53]).

Model	Prediction	n	AUC	p Value vs. PSA	p Value vs. T2:ERG or PCA3
PSA	Cancer	1225	0.585	NA	NA
PSA plus T2:ERG			0.693	<0.001	NA
PSA plus PCA3			0.726	<0.001	<0.05
PSA plus T2:ERG plus PCA3 (MiPS)			0.751	<0.001	<0.001, <0.001
PSA	HG cancer	1225	0.651	NA	NA
PSA plus T2:ERG			0.729	<0.001	NA
PSA plus PCA3			0.747	<0.001	NS
PSA plus T2:ERG plus PCA3 (MiPShg)			0.772	<0.001	<0.01, <0.001

AUC: area under the curve; HG: high grade; MiPS: Mi-Prostate Score; MiPShg: Mi-Prostate Score, high grade; NA: not available; NS: not significant; PSA: prostate-specific antigen; T2:ERG: TMPRSS2:ERG; PCA3: prostate cancer antigen 3.