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. 2017 Mar 7;14(3):270. doi: 10.3390/ijerph14030270

Table 3.

Clinical implications of PCA3 plus TMPRSS2-ERG assays (adapted from [56]).

Model Prostate Biopsies Avoided (n = 443) n (%) Prostate Cancers Missed (n = 196) n (%) Prostate Cancers Gleason ≥ 7 Missed (n = 115) n (%)
PCA3 score ≥ 25 166 (37) 37 (19) 20 (17)
PCA3 score ≥ 35 211 (48) 62 (32) 36 (31)
TMPRSS2-ERG ≥ 10 382 (86) 150 (77) 75 (65)
PCA3-25 plus TMPRSS2-ERG 153 (35) 26 (13) 11 (10)
PCA3-35 plus TMPRSS2-ERG 195 (44) 48 (24) 24 (21)

TMPRSS2-ERG: v-ets erythroblastosis virus E26 oncogene homolog; PCA3 score: [copies PCA3 mRNA]/[copies PSA mRNA] × 1000; TMPRSS2-ERG positive: ≥ 10 copies TMPRSS2-ERG mRNA; PCA3-25 plus TMPRSS2-ERG: TMPRSS2-ERG positive and/or PCA3 ≥ 25; PCA3-35 plus TMPRSS2-ERG: TMPRSS2-ERG positive and/or PCA3 ≥ 35.