A: Schematic of experimental paradigm. The P12 rat pups, approximately equal to 6-month-old human infants, underwent CCI. A subset of P15 sham and CCI-veh rats underwent studies in the acute period at 72 hours after CCI (49 rats). For chronic studies (76 rats), CCI rats were randomized to receive 3000 U/kg of EPO or vehicle on PID1, 2, 3, 4, 6, and 8 and underwent analysis beginning at P28 (PID16). B: Regions of interest used for DTI analysis for the ipsilateral and contralateral white matter (thin strips) and cortex (wide strips). Figure is available in color online only.