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. 2017 Mar 28;4:170033. doi: 10.1038/sdata.2017.33

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 Metadata associated with this Data Descriptor is available at http://www.nature.com/sdata/ and is released under the CC0 waiver to maximize reuse.

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(a) Across the neuroblastoma cell lines, 3,940 genes were differentially-expressed (DE) based on MYCN amplification status and of those, 2,395 were differentially-expressed based on MYCN amplification status in primary tumors and were significantly correlated (Pearson’s R=0.824, P<2.2 e-16). (b) The fold changes of these DE genes were significantly correlated between the cell line dataset and the patient tumor dataset (Pearson’s R=0.73, P<2.2 e-16). (c) A significant correlation between the common 6,523 genes that were not DE in cell lines and tumors was observed (Pearson’s R=0.829, P<2.2 e-16). (d) As expected, correlation of the non-DE genes’ fold changes was close to zero (Pearson’s R=0.052, P<3 e-5).