Table 3. Genetic lesion profiles for the neuroblastoma cell lines.

Cell Line	MYCN status	1p36 del	3p26 del	11q23 del	17q21-qter unbal gain	ALK mutation	p53 mutation
Listed are collated data for common genetic lesions in neuroblastoma: MYCN amplification status, 1p24, 3p25, and 11q26 deletion status, 17q unbalanced gain27 status, ALK mutation status18, and TP53 mutation status18. Alterations for 1p, 3p, 11q, and 17q are reported from both visual inspection of SNP arrays in Illumina’s Genome Studio as well as processed files from Nexus Copy Number software (Biodiscovery, El Segundo, CA); see Data Citation 3 (del=deletion, cnLOH=copy neutral loss of heterozygosity, AI=allelic imbalance).
CHP-134	Amplified	LOH p32.3-pter; Gain p34.3-p36.22; Loss p36.22-pter	Gain/AI p26.3	None	Gain q12-qter	WT	WT
CHP-212	Amplified	Loss p13.2-pter	Gain/AI p26.3	cnLOH 23.3	Gain q12-qter	WT	WT
COG-N-415	Amplified	Unknown	Unknown	Unknown	Unknown	F1174L	WT
COG-N-440	Amplified	Unknown	Unknown	Unknown	Unknown	WT	WT
COG-N-453	Amplified	Unknown	Unknown	Unknown	Unknown	F1174L	WT
COG-N-471nb	Amplified	Unknown	Unknown	Unknown	Unknown	WT	WT
COG-N-496	Amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
COG-N-519	Amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
COG-N-534	Non-amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
COG-N-549	Non-amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
COG-N-557nb	Amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
COG-N-561	Amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
COG-N-573	Amplified	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown
FELIX (COG-N-426)	Non-amplified	Unknown	Unknown	Unknown	Unknown	F1245C	WT
IMR-05	Amplified	Gain+LOH p32.3-pter	Gain/AI p24.3-26.3	Loss q22.1-qter	Gain q21.2-qter	WT	WT
IMR-32	Amplified	Loss p32.3-pter	Loss p12.3	cnLOH q23.1	Gain q21.2-qter	WT	WT
KELLY	Amplified	LOH p21.3-pter; Loss p36.32; Gain p36.33	Loss p26.2	Loss q23.3-qter	Gain q21.2-qter	F1174L	P177T
LA-N-5	Amplified	Loss p33-pter	None	None	Gain q21.2-qter	R1275Q	WT
LA-N-6	Non-amplified	p36.12-pter; cnLOH p35.3-p36.11	Loss p14.3-pter	Loss q13.4-qter	Gain q12-qter	WT	WT
NB-1	Amplified	Loss p32.2-pter	Gain p24.1-pter	cnLOH q23.1	Gain q22-qter	WT; amplified	WT
NB-16	Non-amplified	None	None	None	Unresolvable	WT	R248W, R175H
NB-1,643	Amplified	Loss p34.2-pter	None	Loss q23.1-qter	Gain q21.31-qter	R1275Q	WT
NB-1,691	Amplified	None	Loss p26.1	LOH q11-qter; Loss q22.1-q24.3	None?	WT	WT
NB-69	Non-amplified	Loss p13.3-pter	None	cnLOH q23.1, q23.3	Gain q12-qter	WT	WT
NB-EBc1	Non-amplified	Loss p35.2-pter	Gain p26.1-pter	Loss q21-24.2	Gain q21.31-qter	WT	WT
NB-SD	Amplified	Loss p21.3-pter	Loss p13-pter	cnLOH q23.2-23.3	Gain q12-qter	F1174L	C176F
NBL-S	Non-amplified	None	None	Loss q14.1-qter	None	WT	WT
NGP	Amplified	cnLOH p32.3-pter	Gain p25.3-pter	Loss q22.1-qter	Gain q21.1-qter	WT	A159D, C141W
NLF	Amplified	Loss p32.2-pter	Loss/AI p26.1; AI p26.2; Gain 26.3	Loss/AI q23.3-qter	Gain q21.2-qter	WT	V203M
NMB	Amplified	cnLOH p34.2-pter	None	Loss q21-qter	LOH/Gain q11.2-qter	WT	G245S
RPE-1	Non-amplified	Unknown	Unknown	Unknown	Unknown	WT	WT
SH-SY5Y	Non-amplified	None	None	Loss q22.1-q24.2	Gain q21.31-qter	F1174L	WT
SK-N-AS	Non-amplified	Loss p36.22-36.32	Loss p14.2-pter	q13.4-qter	Gain q21.31-qter	WT	H168R
SK-N-BE(2)	Amplified	cnLOH p21.3-pter	Loss p14.2-pter	Gain/AI q13.1-qter	Gain q12-qter	WT	C135F
SK-N-BE(2)-C	Amplified	cnLOH p21.3-pter	Loss p14.2-pter	LOH q11-qter; Gain q13.4-qter	Gain q12-qter	WT	C135F
SK-N-DZ	Amplified	None	Gain/AI p26.1-pter	Loss q21-qter	Gain q21.2-qter	WT	R110L
SK-N-FI	Non-amplified	None	None	None	Gain q21.31-qter	WT	M246R
SK-N-SH	Non-amplified	None	None	None	Gain q21.31-qter	F1174L	WT
SMS-KAN	Amplified	Loss p13.3-pter	None	Loss q14.2-q23.3	Gain q11.1-qter	WT	WT
SMS-SAN	Amplified	Loss p32.3-pter	None	Loss q25	Gain q21.2-qter	F1174L	WT