Fig. 1.

MBP staining of HSPD1 (D29G)-transgenic mice (B) and the littermate controls (A). Neonatal mouse brains were sliced along an anterior and posterior axis and immunostained with BioLegend, Inc.'s anti-MBP antibody (red), following with secondary fluorescent antibodies. Transgenic mice express the HSPD1 construct (see supplementary data) and exhibit decreased myelin formation. Scale bar indicates 500 μm. Line 1 is drawn along corpus callosum. Red color intensities along lines 1 and 2 are shown in two lower graphs. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)