. Author manuscript; available in PMC: 2017 Mar 28.

Published in final edited form as: Nat Rev Neurosci. 2016 Jul 28;17(9):562–575. doi: 10.1038/nrn.2016.87

Table 1.

Afferents and efferents of the dentate gyrus

Hippocampal afferents		Extra-hippocampal afferents	Efferents to dentate gyrus		Efferents to CA3
Glutamatergic	GABAergic	Extra-hippocampal afferents	Glutamate	GABA	Efferents to CA3
Outer molecular layer
Not applicable	HIPP^13–15 MOPP^13–15 NG cell¹³⁵	LPP^4,5 NA⁹¹ 5-HT⁹¹	Not applicable	MOPP^13–15 NG cell¹³⁵	Not applicable
Middle molecular layer
Not applicable	HIPP^13–15 MOPP^13–15 NG¹³⁵	MPP^4,5 NA⁹¹ 5-HT⁹¹	Not applicable	MOPP^13–15 NG¹²³	Not applicable
Inner molecular layer
MC^{6–8,25,26,49,41} vCA3 (REF. 81)	HICAP^13,15	ACh¹³⁸ Mamm^139–141	smGC^9–10	Multiple¹⁶	smGC^9–10
Granule cell layer
Not applicable	BC^13–15 AA cell^13–15	Mamm¹³⁹	mGC^3,31 abGC¹²	BC^13–15 AA cell¹²⁶	mGC^3,31 abGC¹²
Hilus
GC^3,34 MC^7,8,35 CA3 (REFS 74–76,78)	Multiple¹⁶	NA^78,91,92 5-HT⁹¹ DA^91,92,132 ACh¹³³	MC^7,8,35 eGC¹¹ smGC^9–10 mGC^3,31 abGC¹⁴⁰	HIPP^13–15 HICAP^13–15 Other¹⁶	eGC¹¹

The table lists the neuronal subtypes that innervate each layer of the dentate gyrus. 5-HT, 5-hydroxytryptamine; AA, axo-axonic; abGC, adult-born granule cell; ACh, acetylcholine; BC, basket cell; DA, dopamine; eGC, ectopic granule cell; GC, granule cell; HICAP, interneurons with a hilar cell body with axon targeting the commissural/associational pathway; HIPP, hilar cells that project to the terminal zone of the perforant path; LPP, lateral perforant path; Mamm, supramammillary; MC, mossy cell; mGC, mature granule cell; MOPP, interneurons with a molecular layer cell body that project to the terminal zone of the perforant path; MPP, medial perforant path; NA, noradrenaline; NG, neurogliaform; smGC, semilunar granule cell; vCA3, ventral CA3.