Figure 1.

Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in DKO mice injected with vector or vehicle control. DKO mice were injected intravenously (i.v.) with 7.5 × 10¹¹ GC/kg, 7.5 × 10¹² GC/kg, or 6.0 × 10¹³GC/kg of AAV8.TBG.mLDLR, 6.0 × 10¹³ GC/kg of AAV8.TBG.hLDLR, or vehicle control (100 μL of phosphate-buffered saline [PBS]). (A) AST and (B) ALT levels were measured in serum samples taken at the time of necropsy by Antech Diagnostics. Values expressed as mean ± standard error of the mean (SEM). Statistically significant elevations in AST and ALT levels relative to controls at the same necropsy time point are indicated (*p < 0.05; n = 7/sex/group).