Table 1. Experimental association constants for [Pt(R-dien)L]2+ (PtN4) complexes with N-AcTrp (black) and the C-terminal ZF2 of HIV1NCp7 (parentheses). Figures for the full NCp7 peptide are in (bold parentheses).
| L |
K
a (×103) M–1
|
|||
| [Pt(dien)L]2+ | [Pt(N-Medien)L]2+ | [Pt(N,N′-Me2dien)L]2+ | [Pt(N,N′-Me4dien)L]2+ | |
| 7-MeGua | 9.01 ± 0.09 | — | — | — |
| (10.42 ± 0.29) | — | — | — | |
| Ino | 5.63 ± 0.3 | — | — | — |
| (3.20 ± 0.29) | — | — | — | |
| 9-EtGua | 6.88 ± 0.36 | 13.52 ± 0.48 | 7.40 ± 0.93 | 11.78 ± 1.02 |
| (13.10 ± 0.94) | (14.70 ± 1.60) | (12.02 ± 0.37) | (18.30 ± 0.34) | |
| (20 ± 0.08) | ||||
| Guo | 13.10 ± 1.29 | 12.78 ± 0.22 | 6.84 ± 0.67 | 15.19 ± 1.21 |
| (15.80 ± 2.83) | (12.11 ± 1.13) | (11.37 ± 2.01) | (9.16 ± 1.46) | |
| (14 ± 0.05) | ||||
| Xan | 16.13 ± 1.10 | 11.56 ± 0.33 | 11.74 ± 0.53 | (11.30 ± 0.36) |
| (46.64 ± 0.28) | (60.22 ± 2.18) | (35.80 ± 0.76) | (48.67 ± 0.29) | |
| (46.91 ± 0.06) | — | |||