Table 1.
Changes in statin pharmacokinetics in cirrhosis*
| Drug | Change in Cmax | Change in AUC |
|---|---|---|
| Lipitor (atorvastatin) | ||
| CTP class A | ↑ 4.0-fold | ↑ 4.0-fold |
| CTP class B | ↑ 16.0-fold | ↑ 11.0-fold |
| Crestor (rosuvastatin) | ||
| CTP class A | ↑ 1.6-fold | ↑ 1.05-fold |
| CTP class B | ↑ 2.0-fold | ↑ 1.21-fold |
| Livalo (pitavastatin) | ||
| CTP class A | ↑ 1.3-fold | ↑ 1.6-fold |
| CTP class B | ↑ 2.7-fold | ↑ 3.8-fold |
| Pravachol (pravastatin) | ||
| Cirrhosis (CTP class not specified) | ↑ 1.34-fold | ↑ 1.52-fold |
| Lescol (fluvastatin) | ||
| Cirrhosis (CTP class not specified) | ↑ 2.5-fold | ↑ 2.5-fold |
*Currently available data from package inserts.
AUC, area under the curve; CTP, Child–Turcotte–Pugh.