Table 1. Baseline characteristics of 3C participants.
| Characteristic | Individuals included in analyses, n = 7,470 | Individuals not included in analyses*, n = 1,824 | p-Value |
|---|---|---|---|
| Age, years | 73.83 ± 5.32 | 76.29 ± 6.30 | <0.0001 |
| Women | 4,558 (61.02) | 1,086 (59.54) | 0.2466 |
| Triglycerides, mmol/l** | 1.25 ± 0.61 | 1.34 ± 0.68‡ | <0.0001 |
| Total cholesterol concentration, mmol/l | 5.82 ± 0.97 | 5.81 ± 1.08‡ | 0.6979 |
| HDL-C concentration, mmol/l | 1.62 ± 0.40 | 1.55 ± 0.43‡ | <0.0001 |
| LDL-C concentration, mmol/l | 3.63 ± 0.85 | 3.64 ± 0.93‡ | 0.7313 |
| Hypercholesterolemia | 4,258 (57.00) | 845 (59.97)‡ | 0.0386 |
| Lipid-lowering drug intake | 2,298 (30.76) | 495 (27.14) | 0.0025 |
| Systolic blood pressure, mm Hg | 146.34 ± 21.64 | 147.70 ± 22.63 | 0.0207 |
| Diastolic blood pressure, mm Hg | 82.36 ± 11.20 | 81.58 ± 11.97 | 0.0128 |
| Hypertension | 5,732 (76.73) | 1,473 (81.34) | <0.0001 |
| Ever smoker | 2,890 (38.70) | 696 (38.20) | 0.6921 |
| Diabetes | 696 (9.35) | 216 (16.65)‡ | <0.0001 |
| BMI | 25.65 ± 4.00 | 25.68 ± 4.32 | 0.7477 |
| APOEε4 carrier | 1,489 (20.03) | 289 (23.27)‡ | 0.0089 |
| History of cardiovascular disease | 661 (8.85) | 247 (13.59) | <0.0001 |
| Educational level | <0.0001§ | ||
| No education | 107 (1.43) | 91 (5.02) | |
| Primary school | 2,194 (29.37) | 710 (39.14) | |
| No education/primary school categories combined | 2,301 (30.80) | 801 (44.16) | |
| Secondary school with certificate of vocational aptitude | 993 (13.29) | 319 (17.58) | |
| Secondary school with secondary education certificate | 1,270 (17.00) | 210 (11.58) | |
| Secondary school categories combined | 2,263 (30.29) | 529 (29.16) | |
| Baccalaureate or equivalent | 1,049 (14.04) | 160 (8.82) | |
| University or equivalent | 1,857 (24.86) | 324 (17.86) | |
| Mini-Mental State Examination score† | 27.64 ± 1.55 | 25.11 ± 3.40 | <0.0001 |
Values are mean ± standard deviation or number (percentage). Body mass index (BMI) was calculated as the ratio of weight (in kilograms) to the square of height (in meters). Diabetes was defined as fasting blood glucose ≥ 7 mmol/l or antidiabetic drug intake or medical history of diabetes. Hypercholesterolemia was defined as fasting total cholesterol ≥ 6.2 mmol/l or lipid-lowering drug intake. Hypertension was defined as systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg or antihypertensive drug intake.
*Excluded for brain tumor, prevalent dementia, or Mini-Mental State Examination score < 24 at baseline, or missing data for lipid concentrations, educational level, Mini-Mental State Examination score, or follow-up data.
**Triglycerides were log-transformed for analyses.
‡>10% missing data.
§For the comparison of individuals with either no education or primary school versus the other categories.
†Number of good answers.
HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.