Table 2. Associations between baseline lipid concentrations and 13-y incident dementia using Cox models.
| Model and outcome | TGs | HDL-C | LDL-C | TC | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n/N | HR (95% CI) | p-Value | n/N | HR (95% CI) | p-Value | n/N | HR (95% CI) | p-Value | n/N | HR (95% CI) | p-Value | |
| Model 1: adjusted for sex, education, center, education × log(age)† | ||||||||||||
| All dementia | 778/7,466 | 1.11 (1.03, 1.19) | 0.0044 | 779/7,467 | 0.92 (0.86, 1.00) | 0.0431 | 776/7,440 | 1.07 (1.00, 1.15) | 0.0511 | 779/7,470 | 1.07 (1.00, 1.15) | 0.0563 |
| Alzheimer disease | 531/7,466 | 1.06 (0.97, 1.16) | 0.1693 | 532/7,467 | 0.95 (0.87, 1.04) | 0.2580 | 529/7,440 | 1.13 (1.04, 1.22) | 0.0045 | 532/7,470 | 1.12 (1.03, 1.22) | 0.0072 |
| Mixed or vascular dementia | 154/7,466 | 1.21 (1.04, 1.41) | 0.0163 | 154/7,467 | 0.90 (0.76, 1.07) | 0.2260 | 154/7,440 | 0.99 (0.85, 1.16) | 0.9140 | 154/7,470 | 1.01 (0.86, 1.19) | 0.8906 |
| Model 2: adjusted for sex, education, center, education × log(age)†, vascular risk factors‡ | ||||||||||||
| All dementia | 761/7,376 | 1.05 (0.97, 1.15) | 0.2424 | 761/7,376 | 0.98 (0.90, 1.08) | 0.6924 | 761/7,376 | 1.10 (1.02, 1.18) | 0.0153 | 762/7,402 | 1.09 (1.01, 1.18) | 0.0263 |
| Alzheimer disease | 522/7,376 | 1.00 (0.90, 1.11) | 0.9909 | 522/7,376 | 0.97 (0.87, 1.09) | 0.6250 | 522/7,376 | 1.16 (1.06, 1.27) | 0.0009 | 523/7,402 | 1.15 (1.05, 1.26) | 0.0028 |
| Mixed or vascular dementia | 150/7,376 | 1.16 (0.95, 1.41) | 0.1406 | 150/7,376 | 1.05 (0.85, 1.29) | 0.6570 | 150/7,376 | 0.98 (0.83, 1.17) | 0.8620 | 150/7,402 | 1.01 (0.85, 1.20) | 0.9178 |
| Model 3: adjusted for sex, education, center, education × log(age)†, vascular risk factors‡, APOEε4 carrier status | ||||||||||||
| All dementia | 755/7,344 | 1.07 (0.98, 1.17) | 0.1374 | 755/7,344 | 0.99 (0.91, 1.09) | 0.8905 | 755/7,344 | 1.06 (0.99, 1.15) | 0.1123 | 756/7,369 | 1.06 (0.98, 1.15) | 0.1258 |
| Alzheimer disease | 518/7,344 | 1.02 (0.91, 1.13) | 0.7669 | 518/7,344 | 0.99 (0.88, 1.10) | 0.8280 | 518/7,344 | 1.12 (1.03, 1.23) | 0.0110 | 519/7,369 | 1.12 (1.02, 1.23) | 0.0171 |
| Mixed or vascular dementia | 149/7,344 | 1.17 (0.96, 1.42) | 0.1206 | 149/7,344 | 1.07 (0.87, 1.32) | 0.5050 | 149/7,344 | 0.96 (0.81, 1.14) | 0.6130 | 149/7,369 | 0.99 (0.83, 1.18) | 0.9101 |
Results are given per standard deviation of lipid fraction (TG = 0.417; LDL = 0.854; HDL = 0.401; TC = 0.974).
†Age represents age at last follow-up or dementia.
‡Vascular risk factors for HDL-C, LDL-C, TGs: the three lipid fractions, body mass index, antihypertensive drug intake, systolic blood pressure, lipid-lowering drug intake, smoking status, diabetes, history of cardiovascular disease, antihypertensive drug intake × log(age). Vascular risk factors for TC: TGs, body mass index, antihypertensive drug intake, systolic blood pressure, lipid-lowering drug intake, smoking status, diabetes, history of cardiovascular disease, antihypertensive drug intake × log(age);
HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TGs, triglycerides.