Table 1.
Patient characteristics and their referral outcomes
| Bethesda criterion | No of patients | Total | Lynch syndrome screening with MSI/IHC assessment | Referred for germline genetic testing | |
|---|---|---|---|---|---|
| Imperial | Oxford | ||||
| Age <50 years | 38 | 17 | 55 | 15 | 5 |
| Further colorectal cancer, or other cancer associated with Lynch syndrome | 16 | 2 | 18 | 4 | 4 |
| Age <60 years, and histology suggestive of significant microsatellite instability | 2 | 5 | 7 | 2 | 0 |
| Lynch syndrome-associated tumour in 1 first degree relative <50 years | 1 | 0 | 1 | 1 | 0 |
| Lynch syndrome-associated tumour in 2 first- or second-degree relatives (any age) | 1 | 0 | 1 | 0 | 0 |
IHC, immunohistochemistry; MSI, microsatellite instability.