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. 2017 Mar 28;12(3):e0174396. doi: 10.1371/journal.pone.0174396

Table 1. Quantitative staining analysis of cellular activity.

	5 days postoperative			14 days postoperative			28 days postoperative			56 days postoperative
	WT	Cpa3^Cre/+	p value	WT	Cpa3^Cre/+	p value	WT	Cpa3^Cre/+	p value	WT	Cpa3^Cre/+	p value
	(n = 6–10)	(n = 7–9)		(n = 6–13)	(n = 7–10)		(n = 8–9)	(n = 8–10)		(n = 5–6)	(n = 5–9)
Cortex
aTB (#/mm²)	0	0	1.000	0.4 ± 1.1^b	0	0.268	1.6 ± 1.3^b	0	0.001	0.7 ± 0.7^b	0	0.016
CD34 (%)	0.35±0.20	0.24±0.21	0.309	0.69±0.35^a	0.70±0.28^b	0.942	0.80±0.19^b	1.31±0.26^b	0.002	0.63±0.18	1.02±0.28^b	0.046
ALP (%)	2.22±1.08	2.25±1.98	0.970	5.09±1.34^a	6.59±2.48^b	0.090	7.41±2.19^b	5.98±2.13^a	0.192	9.08±3.02^b	7.64±2.98^b	0.410
TRAP (%)	0.07±0.12	0.01±0.02	0.232	3.70±2.33^b	3.88±3.80^b	0.898	1.33±0.61	2.63±1.39^a	0.025	0.57±0.28	1.30±0.62^a	0.025
F4/80 (#/mm²)	0.16±0.06	0.14±0.13	0.774	0.28±0.08	0.39±0.13^a	0.103	0.21±0.06	0.40±0.19^a	0.017	0.44±0.21^a	0.21±0.09	0.081
Defect/Medulla
aTB (#/mm²)	0	0	1.000	10.0 ± 5.9^b	0	<0.001	8.0 ± 3.4^b	0	<0.001	4.9 ± 4.1^b	0	0.005
CD34 (%)	0.31±0.31	0.14±0.10	0.161	0.87±0.40^b	0.92±0.57^b	0.810	0.27±0.09	0.45±0.18^a	0.035	0.10±0.06	0.22±0.05	0.016
ALP (%)	0.01±0.01	0.02±0.03	0.384	5.16±1.92^b	4.37±2.11^b	0.378	3.54±1.25^b	2.14±0.84^a	0.014	2.09±0.78^a	2.11±1.54^a	0.983
TRAP (%)	0.35±0.44	0.01±0.02	0.047	5.56±2.99^b	3.68±2.13^b	0.122	1.10±0.63	1.63±0.85^a	0.161	0.29±0.15	0.82±0.30^a	0.002
F4/80 (#/mm²)	0.72±0.51	0.36±0.29	0.171	3.59±1.24^b	2.27±0.67^b	0.047	4.03±0.74^b	2.96±0.64^b	0.009	3.05±0.49^b	3.38±0.76^b	0.486

aTB mast cells; CD34 vascular endothelial cells; ALP osteoblasts; TRAP osteoclasts; F4/80 macrophages. Significantly different from 5 days postoperative

^a p <0.05 and

^b p <0.01.