Table 3.
Change in variables from baseline to latest clinic visit for subgroups with abnormalities at baseline
| Subgroup | Measure | Number | Baseline | Recent | Δ (%) | p Value |
|---|---|---|---|---|---|---|
| Raised ALT | ALT, U/l | 145 | 66 (41–270) | 55 (14–221) | −16.7 | <0.001 |
| Obese | Weight, kg | 101 | 101.0 (64.8–175.0) | 96.9 (62.0–175.3) | −4.9 | <0.001 |
| Diabetes | HbA1c, mmol/mol | 77 | 53 (36–120) | 52 (32–105) | −1.9 | 0.018 |
| Dyslipidaemia | tChol, mmol/l | 99 | 4.95 (2.80–7.95) | 4.43 (2.39–7.12) | −10.5 | <0.001 |
| Dyslipidaemia | HDL, mmol/l | 99 | 1.02 (0.59–1.75) | 1.01 (0.53–1.92) | −1.0 | 0.24 |
| Dyslipidaemia | TG, mmol/l | 99 | 2.17 (0.58–7.85) | 1.87 (0.34–7.94) | −13.8 | <0.001 |
| Hypertension | SBP, mm Hg | 95 | 143 (105–191) | 136 (104–176) | −4.9 | 0.012 |
| Hypertension | DBP, mm Hg | 95 | 82 (68–114) | 82 (66–108) | 0 | 0.018 |
Data expressed as median (range).
Definitions: raised ALT greater than 40 U/l; Obese, body mass index ≥30 kg/m2; dyslipidaemia and diabetes as per WHO proposal (1999). Number refers to the number of patients with paired data available for this variable.
Bold values represent significant values.
ALT, alanine aminotransferase; DBP, diastolic blood pressure; HbA1c, glycosylated haemoglobin; HDL, high density lipoprotein; SBP, systolic blood pressure; tChol, total cholesterol; TG, triglyceride.