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. 2017 Feb 5;8(10):16122–16143. doi: 10.18632/oncotarget.15109

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Copyright: © 2017 Nagaraj et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Regulatory network of 9 novel (A.) and 6 previously reported (B.) AD biomarker candidate miRNAs and their putative cellular effectors. Putative targets were identified by searching the MirTarBase (version 6) database which contains experimentally validated miRNA target genes followed by KEGG’s database search for pathways contributing to neurodegenerative diseases and pathways of the nervous system. For construction of miRNA regulatory network only target genes/proteins that had 2 or more hits were considered. In A, the inner circle contains targets common for at least 4 up to 6 miRNAs, the middle layer contains targets common for 3 miRNAs, and the outer layer contains targets for 2 miRNAs. In B, targets shown are for 2 miRNAs. Highlighted are the miRNAs with higher number of hits to putative protein targets.

Regulatory network of 9 novel (A.) and 6 previously reported (B.) AD biomarker candidate miRNAs and their putative cellular effectors. Putative targets were identified by searching the MirTarBase (version 6) database which contains experimentally validated miRNA target genes followed by KEGG’s database search for pathways contributing to neurodegenerative diseases and pathways of the nervous system. For construction of miRNA regulatory network only target genes/proteins that had 2 or more hits were considered. In A, the inner circle contains targets common for at least 4 up to 6 miRNAs, the middle layer contains targets common for 3 miRNAs, and the outer layer contains targets for 2 miRNAs. In B, targets shown are for 2 miRNAs. Highlighted are the miRNAs with higher number of hits to putative protein targets.