Table 8. Predicted binding sites in AD-related transcripts for the differential 15 miRNAs in AD plasma.

Target gene	miRNAs	miRNA and their seed region matching site in the 3′UTR region of gene
APP	hsa-miR-1260a hsa-miR-320a/b/c	hsa-miR-1260a : 80-86 hsa-miR-320a/b/c : 2355-2361 2743-2750
BACE 1	hsa-miR-200a-3p hsa-miR-1260a hsa-miR-320a/b/c	hsa-miR-200a-3p : 1551-1558 hsa-miR-1260a : 1559-1565 hsa-miR-320a/b/c : 3216-3222
BACE 2	hsa-miR-483-5p	hsa-miR-483-5p : 103-109 3798-3804
MAPT (Tau)	hsa-miR-151a-3p hsa-miR-483-5p hsa-miR-320a/b/c	hsa-miR-151a-3p : 101-107 hsa-miR-483-5p : 1143-1149 hsa-miR-320a/b/c : 2795-2801 3885-3891
PSEN2	hsa-miR-30b-5p	hsa-miR-30b-5p : 121-127

Search was performed with Targetscan 7.1 software. APP- Amyloid Beta Precursor Protein; BACE 1- Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1; BACE 2- Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2; MAPT- Microtubule-Associated Protein Tau (Tau Protein); PSEN2- Presenilin 2.