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. 2015 May 7;8(10):16202–16219. doi: 10.18632/oncotarget.3892

Figure 7. p63 regulates the expression and/or activation of AKT, c-Jun and matrix metalloproteinase-14 (MMP14).

Figure 7

A. Protein levels of pAKT-S473, total AKT, total c-Jun, MMP14 and β-actin; and B. the relative mRNA levels of c-Jun and MMP14 after transient knockdown by Scram (control) and two different p63 siRNA molecules in late passage human foreskin keratinocytes (HFK) expressing human papilloma virus (HPV)16 E6/E7 genes. C. Immunofluorescence detections of p-c-Jun-S73 and BrdU uptake on 3D-organotypic rafts established from late passage HFK after stable p63 (p63 shRNA) knockdown compared to its control (scram shRNA). The invasive incidents are indicated by arrows. Scale bar represent 100 μm. N = 3 independent experiments, mean ± SEM, *p < 0.05 compared to the controls.