. 2016 Jul 22;8(10):16313–16324. doi: 10.18632/oncotarget.10771

Table 2. Association between MDM4 SNPs and OS of patients in each set and in pooled populations.

SNPs	Discovery set					Replication set					Pooled
SNPs	N	mOS (95% CI) (m)^a	P_L-R	aHR (95% CI)^b	P^b	N	mOS (95% CI) (m)^a	P_L-R	aHR (95% CI)^b	P^b	N	mOS (95% CI) (m)^a	P_L-R	aHR (95% CI)^b	P^b
rs10900598
AA	476	17.80 (15.44-20.16)	0.017	Ref.		233	16.40 (13.64-19.16)	0.007	Ref.		709	17.57 (15.93-19.21)	2.15* 10^-4	Ref.
AC	115	20.00 (17.45-22.55)		0.86 (0.68-1.10)	0.227	73	24.03 (17.85-30.22)		0.77 (0.57-1.06)	0.107	188	21.27 (18.11-24.42)		0.83 (0.69-1.00)	0.055
CC	49	25.77 (15.92-35.61)		0.65 (0.46-0.93)	0.017	24	29.77 (23.57-35.96)		0.49 (0.29-0.82)	0.007	73	27.43 (22.35-32.51)		0.60 (0.45-0.80)	0.001
dominant
CC+AC	164	21.90 (18.73-25.07)	0.008	0.79 (0.64-0.97)	0.026	97	25.60 (21.17-30.03)	0.004	0.68 (0.51-0.91)	0.008	261	22.63 (20.07-25.19)	1.59* 10^-4	0.75 (0.64-0.89)	0.001
AA	476	17.80 (15.44-20.16)		Ref.		233	16.40 (13.64-19.16)		Ref.		709	17.57 (15.93-19.21)		Ref.
recessive
CC	49	25.77 (15.92-35.61)	0.023	0.67 (0.47-0.95)	0.025	24	29.77 (23.57-35.96)	0.012	0.52 (0.31-0.88)	0.013	73	27.43 (22.35-32.51)	0.001	0.62 (0.47-0.83)	0.001
AA+AC	591	18.67 (16.97-20.36)		Ref.		306	17.90 (15.67-20.13)		Ref.		897	18.30 (16.91-19.69)		Ref.
additive		NA	NA	0.82 (0.71-0.96)	0.011		NA	NA	0.73 (0.59-0.90)	0.003		NA	NA	0.79 (0.70-0.90)	1.67* 10^-4
rs4245739
AA	568	18.67 (16.83-20.50)	0.015	Ref.		294	17.70 (15.50-19.91)	0.018	Ref.		862	18.00 (16.60-19.40)	0.001	Ref.
AC	61	21.27 (15.07-27.47)		0.71 (0.52-0.98)	0.037	30	27.90 (19.76-36.04)		0.71 (0.46-1.10)	0.121	91	24.47 (18.68-30.26)		0.71 (0.55-0.91)	0.008
CC	13	31.27 (26.49-36.05)		0.50 (0.25-1.02)	0.055	6	30.63 (16.29-44.97)		0.49 (0.18-1.35)	0.166	19	31.27 (27.17-35.36)		0.50 (0.28-0.89)	0.019
dominant
CC+AC	74	25.37 (15.95-34.78)	0.005	0.67 (0.50-0.90)	0.007	36	29.80 (23.58-36.02)	0.006	0.67 (0.44-1.01)	0.051	110	26.40 (20.56-32.24)	2.06* 10^-4	0.67 (0.53-0.85)	0.001
AA	568	18.67 (16.83-20.50)		Ref.		294	17.70 (15.50-19.91)		Ref.		862	18.00 (16.60-19.40)		Ref.
recessive
CC	13	31.27 (26.49-36.05)	0.066	0.52 (0.26-1.05)	0.069	6	30.63 (16.29-44.97)	0.085	0.52 (0.19-1.41)	0.198	19	31.27 (27.17-35.36)	0.017	0.52 (0.29-0.93)	0.026
AA+AC	629	19.10 (17.46-20.74)		Ref.		324	19.03 (16.44-21.70)		Ref.		953	19.07 (17.67-20.46)		Ref.
additive		NA	NA	0.71 (0.56-0.90)	0.005		NA	NA	0.71 (0.50-0.99)	0.043		NA	NA	0.71 (0.59-0.86)	4.99* 10^-4

OS overall survival, m months, Ref. reference, NA not available, HR hazard ratio, CI confidence interval, P_L-R Log-Rank P;

^a survival derived from Kaplan–Meier analysis;

^b HRs, 95% CIs and their corresponding p-values were calculated using multivariate Cox proportional hazard models, adjusted for all clinical factors.