Table 4. Combined effects of MDM4 rs10900598 and rs4245739 in Discovery set and in pooled populations.
| No. ofVariant Alleles | Discovery set | Pooled | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (%) | mOS (95% CI) (m)a | PL-R | aHR (95% CI)b | Pb | N (%) | mOS (95% CI) (m)a | PL-R | aHR (95% CI)b | Pb | |
| 0 | 427 (66.5) | 17.20 (14.85-19.55) | 0.004 | Ref. | 636 (65.4) | 16.27 (14.45-18.08) | 2.0*10-6 | Ref. | ||
| 1 | 147 (22.9) | 19.77 (16.97-22.56) | 0.80 (0.64-1.00) | 0.045 | 231 (23.8) | 21.47 (18.69-24.24) | 0.76 (0.63-0.90) | 0.002 | ||
| 2 | 55 (8.6) | 26.30 (16.69-35.91) | 0.67 (0.48-0.93) | 0.016 | 87 (9.0) | 27.90 (23.42-32.38) | 0.62 (0.48-0.80) | 3.27* 10-4 | ||
| 3 | 9 (1.4) | 31.27 (16.75-45.78) | 0.44 (0.19-1.00) | 0.029 | 14 (1.4) | 33.47 (21.18-45.76) | 0.42 (0.22-0.81) | 0.016 | ||
| 4 | 4 (0.6) | 33.93 (20.86-47.00) | 0.36 (0.09-1.47) | 0.015 | 4 (0.4) | 33.93 (20.86-47.00) | 0.35 (0.09-1.40) | 0.010 | ||
| P trend = 0.010 | P trend = 3.3*10-5 | |||||||||
OS overall survival, m months, Ref. reference, HR hazard ratio, CI confidence interval, PL-R Log-Rank P;
a survival derived from Kaplan–Meier analysis;
b HRs, 95% CIs and their corresponding p-values were calculated using multivariate Cox proportional hazard models, adjusted for all clinical factors.