Table 2. Stratified analysis of pooled hazard ratios of breast cancer patients with reduced E-cadherin expression on OS and DFS.

Stratified analysis	OS					DFS
	Pooled HR (95%CI)		Meta-regression P value	Heterogeneity		Pooled HR (95%CI)		Meta-regression P value	Heterogeneity
	fixed	random		I2	P value	fixed	random		I2	P value
Year		0.937			0.791
< 2010	1.32 (1.12,1.56)	1.85 (1.22,2.81)		79.0%	< 0.001	1.38 (1.20,1.59)	1.69 (1.19,2.40)		79.9%	< 0.001
≥ 2010	1.46 (1.23,1.73)	1.77 (1.30,2.41)	57.4%	0.002	1.49 (1.29,1.73)	1.58 (1.21,1.99)	63.2%	0.001
Nation		0.209			0.925
Asia	1.56 (1.30,1.88)	2.12 (1.45,3.09)		68.9%	< 0.001	1.44 (1.21,1.71)	1.61 (1.13,2.28)		69.6%	< 0.001
Non-Asia	1.27 (1.08,1.48)	1.51 (1.09,2.08)	65.8%	0.001	1.43 (1.27,1.61)	1.63 (1.24,2.14)	74.3%	< 0.001
HR estimate		0.637			0.485
Directly	1.65 (1.30,2.09)	1.77 (1.41,2.28)		55.5%	0.028	1.67 (1.23,2.26)	1.63 (1.40,1.91)		62.4%	0.009
Calculated	0.99 (0.83,1.19)	1.60 (0.93,2.75)	81.3%	< 0.001	1.13 (0.75,1.71)	0.94 (0.79,1.13)	74.1%	0.004
Curves	1.92 (1.55,2.39)	1.92 (1.55,2.39)	0.0%	0.693	1.93 (1.59,2.34)	1.93 (1.59,2.34)	0.0%	0.512
Scoring criteria		0.024			0.423
Percentage	2.19 (1.78,2.70)	2.19 (1.78,2.70)		0.0%	0.613	2.11 (1.52,2.92)	2.13 (1.68,2.70)		38.5%	0.135
Intensity	0.93 (0.74,1.16)	1.21 (0.68,2.15)	72.9%	0.011	1.19 (0.76,1.87)	1.09 (0.92,1.30)	79.6%	0.001
Combined	1.22 (1.00,1.48)	1.33 (0.84,2.10)	74.8%	0.003	1.58 (1.20,2.09)	1.47 (1.27,1.70)	63.3%	0.004
Location		0.061			0.031
M	1.24 (1.09,1.41)	1.57 (1.17,2.10)		71.8 %	< 0.001	1.29 (1.16,1.45)	1.37 (1.07,1.75)		73.8%	< 0.001
C, M	2.80 (1.92,4.10)	2.80 (1.92,4.10)	0%	0.925	3.35 (2.03,5.53)	3.35 (2.03,5.53)	0.0%	0.529
Pathological type
IDC	1.13 (0,97,1.32)	1.61 (1.09,2.39)		78.1%	< 0.001	1.12 (0.95,1.31)	1.58 (1.03,2.44)		82.4%	< 0.001