Table 2. Associations and stratification analysis of VEGFA 2578 C/A polymorphism and HCC risk.
| Variable | Genotypes | HCC (%) n = 476 | Control (%) n = 526 | Adjusted OR (95% CI) | P value |
|---|---|---|---|---|---|
| Age | |||||
| < 55 years | CC | 169 (62.6) | 175 (55.9) | 1.00 | |
| CA + AA | 101 (37.4) | 138 (44.1) | 0.57 (0.38,0.87) | 0.009 | |
| ≥ 55 years | CC | 132 (64.1) | 115 (54.0) | 1.00 | |
| CA + AA | 74 (35.9) | 98 (46.0) | 0.53 (0.33,0.84) | 0.007 | |
| Gender | |||||
| Female | CC | 76 (61.3) | 87 (62.1) | 1.00 | |
| CA + AA | 48 (38.7) | 53 (37.9) | 1.06 (0.60,1.88) | 0.840 | |
| Male | CC | 225 (63.9) | 203 (52.6) | 1.00 | |
| CA + AA | 127 (36.1) | 183 (47.4) | 0.43 (0.29,0.63) | 0.000 | |
| Smoking | |||||
| Yes | CC | 159 (62.1) | 97 (54.5) | 1.00 | |
| CA + AA | 97 (37.9) | 81 (45.5) | 0.61 (0.38,1.00) | 0.054 | |
| No | CC | 142 (64.5) | 193 (55.5) | 1.00 | |
| CA + AA | 78 (35.5) | 155 (44.5) | 0.57 (0.38,0.87) | 0.008 | |
| Drinking | |||||
| Yes | CC | 79 (60.8) | 71 (57.7) | 1.00 | |
| CA + AA | 51 (39.2) | 52 (42.3) | 0.61 (0.32,1.18) | 0.143 | |
| No | CC | 222 (64.2) | 219 (54.3) | 1.00 | |
| CA + AA | 124 (35.8) | 184 (45.7) | 0.57 (0.40,0.82) | 0.002 | |
| HBV | |||||
| HbsAg (+) | CC | 194 (60.2) | 37 (43.5) | 1.00 | |
| CA + AA | 128 (39.8) | 48 (56.5) | 0.53 (0.32,0.86) | 0.011 | |
| HbsAg (–) | CC | 107 (69.5) | 253 (57.4) | 1.00 | |
| CA + AA | 47 (30.5) | 188 (42.6) | 0.60 (0.40,0.89) | 0.010 | |
| Family history of cancer | |||||
| Yes | CC | 29 (64.4) | 24 (51.1) | 1.00 | |
| CA + AA | 16 (35.6) | 23 (48.9) | 0.48 (0.16,1.46) | 0.194 | |
| No | CC | 272 (63.1) | 266 (55.5) | 1.00 | |
| CA + AA | 159 (36.9) | 213 (44.5) | 0.56 (0.41,0.77) | 0.000 |