Table 5. Cox multivariate regression analysis of potential factors for overall survival in patients with resected HCC.
| Variables | Adjusted HR* | (95% CI)* | P* |
|---|---|---|---|
| Tumor size (> 5 cm vs. ≤ 5 cm) | 1.099 | 0.364–3.318 | 0.867 |
| Tumor type (diffuse vs. nodular) | 3.887 | 1.861–8.122 | 0.000 |
| Portal vein invasion (yes vs.no) | 8.622 | 1.403–52.999 | 0.020 |
| Lymph node metastasis (yes vs.no) | 3.566 | 0.610–20.836 | 0.158 |
| Microvascular invasion (yes vs.no) | 3.471 | 1.628–7.401 | 0.001 |
| Microsatellite nodule (yes vs.no) | 1.572 | 0.667–3.703 | 0.301 |
| Edmondson grade (III/IV vs.I/II) | 2.549 | 1.264–5.138 | 0.009 |
| VEGFA 2578 C/A (AA/AC vs. CC) | 0.265 | 0.134–0.524 | 0.000 |
*
HR (95% confidence interval [CI]) and P values for the 2578 genotype for overall survival were adjusted according to important clinical characteristics.