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. 2017 Feb 1;8(10):16518–16530. doi: 10.18632/oncotarget.14965

Figure 5. Histological assessment of tumors reveals reduced cell density, lower proliferation, and elevated apoptosis in response to ChoKα inhibitors.

Figure 5

(A) H&E staining (left column) of MDA-MB-231 tumor xenografts reveals lower cell density in MN58b (middle row) and JAS239 (bottom row) treated tumors compared to vehicle-treated tumors (top row). Reduced Ki67-positive nuclei (middle column) and heightened caspase-3 positive cells (right column) were also found in MN58b and JAS239 treated tumors. Significant (B) reduction in cell density, (C) lower Ki67 positivity, and (D) elevated caspase-3 were observed in both MN58b and JAS239 treated tumors relative to control, indicating apoptosis in response to ChoK inhibition. Scale bars represent 200 μm. Values are reported as ± SEM and n = 3 for each treatment cohort. *indicates P < 0.05.